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Do not take St John's wort, the herbal remedy for depression, while you're being treated with trazodone as this will increase your risk of side effects. This increases levels of serotonin in the nerve synapse (the space between two nerves) Trazodone hydrochloride tablets are indicated for the treatment of major depressive disorder (MDD) in adults. Trazodone is a generic antidepressant prescription medication. It can take 1 to 2 weeks before trazodone starts to work, but it may be 4 to 6 weeks before you feel the full benefit NHS medicines information on trazodone – what it's used for, side effects, dosage and who can take it. Trazodone can be used to treat depression. About trazodone Who can and cannot take it How and when to take it Side effects Pregnancy, breastfeeding and fertility Taking trazodone with other medicines and herbal supplements Common questions Related conditions Clinical depression. 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How it works Trazodone belongs to a class of drugs called antidepressants. Health care practitioners also use it for insomnia and mood disorders such as anxiety and post-traumatic stress disorder (PTSD). Doctors usually prescribe trazodone when other antidepressants have not worked or have caused side effects. It's only available on prescription. It can help patients whose depression has not responded to other medications, or who have experienced limiting side effects with other antidepressants. Here’s what we found when we asked the experts “What is. It is approved by the Food and Drug Administration (FDA) for the treatment of depression. Trazodone was developed in Italy in the 1960s as an antidepressant medication. Trazodone may also be used to treat other conditions such as problems sleeping, anxiety, and panic attacks Trazodone is an older medication approved for use by the FDA in 1981 as an antidepressant. [18] The medication is taken by mouth. 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